Lenvat 10 mg Capsule

Molecule: Lenvatinib

Strength: 10 mg

Quantity: 30 Capsules

Form: Capsule

Packaging Type: Bottle

Manufacturer/Marketed By: Natco Pharma

Country of Origin: India

Product	Manufacturer / Marketed By	Price
Lenvakast Lenvatinib 10 mg Capsule	Aprazer Healthcare	Ask for Price
Lenvima Lenvatinib 10 mg Capsule	Eisai Inc	Ask for Price
Lenvaxen Lenvatinib 10 mg Capsule	Everest Pharma	Ask for Price

Description

Lenvat 10 mg Capsule is a prescription-only medicine that treats certain cancers, including thyroid, kidney, and liver. It contains lenvatinib, which blocks specific proteins that help cancer cells grow and spread throughout the body. By interfering with these proteins, the medicine helps slow down the progression of the disease and may reduce the size of tumors. Natco Pharma Ltd manufactures Lenvat Lenvatinib 10 mg Capsule. Take this medicine strictly under a doctor’s supervision, with regular monitoring during treatment.

Benefits

Lenvat 10 mg slows down the growth of cancer cells in the thyroid, kidney, and liver.
Lenvatinib helps to shrink tumors in affected patients.
Improves overall survival in patients with advanced cancer.
It can delay the spread of cancer to other body parts.
It helps relieve symptoms like pain, pressure, or breathing issues related to tumors.

Indications and Usage

Lenvat 10 mg Capsule is used to treat different types of cancer. Doctors prescribe this medicine when cancer cannot be removed by surgery or has spread to other parts of the body.

It is used to treat:

Thyroid Cancer
- For adults with differentiated thyroid cancer that is progressive (getting worse), and does not respond to radioactive iodine therapy.
Kidney Cancer (Renal Cell Carcinoma)
- Used with another medicine called everolimus to treat advanced kidney cancer in people who have already tried one treatment.
Liver Cancer (Hepatocellular Carcinoma)
- Used as a first-line treatment for unresectable liver cancer (cancer that cannot be removed by surgery).

How it Works

Lenvat 10 mg Capsule contains lenvatinib, a medicine in the tyrosine kinase inhibitor (TKI) group.

What does it do in your body?

Some cancers grow because of special proteins that tell cancer cells to grow, spread, and make blood vessels.
These blood vessels bring food and oxygen to the cancer, helping it grow faster.
Lenvatinib 10 mg blocks these signals, so the cancer cannot grow easily.

What happens when Lenvat 10 mg capsule works?

It stops the cancer cells from growing.
It blocks new blood vessels that feed the cancer.
It helps cancer cells die.
It can shrink the tumor or stop it from getting bigger.

Which proteins does it block?

Lenvatinib blocks several proteins that are very active in cancer:

VEGFR (vascular endothelial growth factor receptor)
FGFR (fibroblast growth factor receptor)
PDGFR (platelet-derived growth factor receptor)
RET and KIT (other proteins that help cancer grow)

By blocking these, Lenvat Lenvatinib 10 mg capsules slow or stop the cancer from growing.

Dosage & Administration

Recommended Dosage of Lenvat 10 mg Capsule

The usual starting dose is 10 mg once per day.
The dose may change based on:
- Type of cancer
- Body weight
- How your body reacts to the medicine
Your treating physician must determine the prescribed dosage based on your condition.

How to Take It

Swallow the capsule whole with a glass of water.
Do not crush, chew, or open the capsule.
If you have trouble swallowing, your doctor might tell you how to mix it with water or juice.

Timing

Take the capsule at the same time every day.
You can take it with or without food.

Frequency

The standard dosage is one capsule (10 mg) daily, unless otherwise directed by your doctor.

Missed Dose

If you forget to take your medicine:
- Take it as soon as you remember.
- If it’s almost time for the next dose, skip the missed one.
- Do not take two doses at the same time.

Overdose Warning

Taking too much of Lenvat 10 mg can be dangerous.
You might get:

Very high blood pressure
Severe bleeding
Liver problems
Serious side effects

If you take too much by mistake, go to the hospital or call your doctor immediately.

Strengths & Substitutes

Strength	Alternative Options
4 mg	Lenvima 4 mg Capsule	Lenvakast 4mg Capsule	Lenvaxen 4mg Capsule
10 mg	Lenvima 10 mg Capsule	Lenvakast 10 mg Capsule	Lenvaxen 10 mg Capsule

Side Effects

Common Side Effects of Lenvat 10 mg Capsule:

High blood pressure
Diarrhea
Loss of appetite
Weight loss
Headache
Fatigue

Less Common but Serious Side Effects

Bleeding problems (nosebleeds, blood in urine or stool)
Liver function problems
Skin changes or peeling
Mouth sores

Severe Reactions – Seek Immediate Help

Severe chest pain
Difficulty breathing
Vision changes
Fainting or irregular heartbeat
Signs of allergic reaction (swelling of face/lips, breathing trouble)

Warning and Precaution

Who Should Avoid This Medication

People with severe liver or kidney problems
Patients with uncontrolled high blood pressure
Pregnant women (can harm the unborn baby)
Breastfeeding mothers may harm their babies.

Drug Interactions

Avoid using with:

Amiodarone

Pimozide

Haloperidol

Sotalol
Thioridazine

Inform your doctor about all medications you are taking.

Food & Lifestyle Considerations

Avoid alcohol (may worsen side effects).

Do not drive or operate machinery if you feel dizzy or tired.

Avoid grapefruit juice, as it may interact with the drug.

Special Warnings

Requires regular blood pressure monitoring.

May require liver function tests during treatment.

Use effective birth control during treatment and for at least 1 month after stopping.

Patient Guidance

Store in a cool, dry place away from sunlight.
Keep out of reach of children.
Take with a full glass of water.
Take it at the same time daily for the best results.
Do not share this medicine with anyone.
Do not use after the expiry date.

Clinical Trial & Approvals

Lenvatinib has been tested in large clinical trials for thyroid, liver, and kidney cancer.

The SELECT trial (392 patients with thyroid cancer) significantly improved progression-free survival.

The REFLECT trial (954 patients with liver cancer) showed similar survival benefits to sorafenib but with better tumor response.
Lenvatinib is FDA-approved and included in NCCN treatment guidelines for relevant cancers.

References

MedlinePlus: Lenvatinib – Drug Information Click here

NCBI Bookshelf: Lenvatinib Summary: Comprehensive medical and clinical profile. Click here

DrugBank: Lenvatinib drug interactions, targets, and mechanisms. Click here

Medscape: Lenvima (Lenvatinib) pharmacology and usage. Click here

Drugs.com: Guidance on lenvatinib usage and risks. Click here

FAQ

What is Lenvat 10 mg used for?+

Lenvat 10 mg is used to treat certain types of cancers, including thyroid cancer, liver cancer (hepatocellular carcinoma), and kidney cancer (renal cell carcinoma).

What is Lenvatinib 10 mg used for?+

Lenvatinib 10 mg is prescribed for treating advanced or metastatic cancers such as thyroid, liver, and kidney cancers.

How does Lenvat 10 mg work?+

Lenvatinib is a multikinase inhibitor that blocks proteins involved in cancer cell growth and blood vessel formation, helping to slow tumor progression.

What are the side effects of Lenvatinib capsules?+

Common side effects include high blood pressure, fatigue, diarrhea, loss of appetite, weight loss, and nausea. Serious side effects can affect the heart, liver, and kidneys.

Which cancers are treated with Lenvatinib?+

Lenvatinib is approved for use in thyroid cancer, hepatocellular carcinoma, and renal cell carcinoma. It may also be used in combination with other drugs for endometrial and other cancers.

How successful is Lenvatinib?+

Lenvatinib has shown to improve progression-free survival and tumor response rates in several cancer types, especially when used as a first-line or combination therapy.

Does Lenvatinib shrink tumors?+

Yes, Lenvatinib can help shrink tumors by blocking the growth of cancer cells and cutting off their blood supply.

How long can you take Lenvatinib?+

The duration depends on individual response and tolerance. It is usually taken as long as it remains effective and side effects are manageable, as directed by your doctor.

Can Lenvat 10 mg capsule cause infertility?+

Yes, Lenvatinib may affect fertility in both men and women. Consult your doctor for fertility preservation options if needed.

Can Lenvat 10 mg capsule cause hair loss?+

Hair thinning or hair loss is a possible but less common side effect of Lenvatinib.

Can Lenvat 10 mg capsule cause heart problems?+

Yes, Lenvatinib can increase the risk of heart problems such as high blood pressure, heart failure, or blood clots. Regular monitoring is advised.

Can Lenvat 10 mg capsule cause vision problems?+

Some patients may experience blurred vision or other eye-related side effects. Report any vision changes to your doctor immediately.

Can Lenvat 10 mg capsule be used in children?+

Lenvatinib is generally not recommended for children unless specifically prescribed by a pediatric oncologist.

Can I undergo tooth extraction while taking Lenvat 10 mg?+

Tooth extraction or other surgeries should be discussed with your doctor, as Lenvatinib may affect wound healing and increase bleeding risk.

What should I do if I miss a dose of Lenvat 10 mg?+

If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose. Do not double the dose.

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