Bevatas 400mg Injection

Brand Name: Bevatas

Molecule: Bevacizumab

Strength: 400 mg

Quantity: 1 Vial

Form: Injection

Packaging Type: Vial

Manufacturer/Marketed By: Intas Pharma

Country of Origin: India

Description

Bevatas 400 mg Injection contains Bevacizumab, an anticancer medicine used as part of combination therapy for the treatment of several advanced and metastatic cancers. It works by inhibiting the formation of new blood vessels that supply oxygen and nutrients to tumors, thereby slowing cancer growth and progression.

Bevatas 400 mg Injection is commonly prescribed along with other chemotherapy medicines for cancers of the breast, brain, cervix, kidney, lung, colon, rectum, ovary, fallopian tube, and primary peritoneum. It may also be used in certain cases of liver cancer.

Effective contraception is required during treatment and for at least 6 months after the last dose, as this medicine may harm an unborn baby and affect fertility. Bevatas 400 mg Injection is not recommended for children and adolescents below 18 years of age. Breastfeeding should be avoided during treatment and for several months afterward, as the medicine may interfere with the child’s growth and development.

Benefits

Helps slow tumor growth by blocking the formation of new blood vessels that supply cancer cells
Enhances the effectiveness of chemotherapy when used in combination treatment regimens
Supports disease control in several advanced and metastatic cancers
May help delay cancer progression and improve treatment outcomes
Targets cancer growth through a specific biological pathway (VEGF inhibition)
Suitable for long-term treatment under specialist supervision in eligible patients

Indications and Usage

Bevatas 400 mg Injection is indicated for use in the treatment of the following cancers, either alone or in combination with other chemotherapy medicines, as prescribed by an oncologist:

Metastatic colorectal cancer
Advanced non-small cell lung cancer (NSCLC)
Glioblastoma multiforme (brain cancer)
Persistent, recurrent, or metastatic cervical cancer
Advanced renal cell carcinoma (kidney cancer)
Metastatic breast cancer
Hepatocellular carcinoma (liver cancer)
Cancers of the ovary, fallopian tube, or primary peritoneum

Bevatas 400 mg Injection is administered intravenously and should be used only under the supervision of a qualified healthcare professional.

How it Works

Bevatas 400 mg Injection contains Bevacizumab, a targeted monoclonal antibody that works by blocking vascular endothelial growth factor (VEGF). VEGF is a protein responsible for the formation of new blood vessels that supply oxygen and nutrients to tumors.

By inhibiting VEGF, Bevatas prevents the development of these blood vessels, reducing the tumor’s blood supply. This helps slow tumor growth, limits cancer spread, and enhances the effectiveness of chemotherapy when used as part of combination treatment.

Dosage & Administration

Bevatas 400 mg Injection is administered as an intravenous (IV) infusion and must be given by a trained healthcare professional in a hospital or clinical setting.

The dose and treatment schedule are determined by the oncologist based on:
- Cancer type and stage
- Body weight
- Overall health and response to treatment
Bevatas is commonly used in combination with other chemotherapy medicines
The infusion is given after dilution, usually over a specified period
The first infusion may be administered slowly and, if well tolerated, subsequent infusions may be given over a shorter duration
Treatment is continued as long as there is clinical benefit and tolerable side effects

Important:

Bevatas 400 mg Injection is not for self-administration
Do not stop or delay treatment without medical advice
Regular monitoring of blood pressure, urine protein, and overall health is required during therapy

Side Effects

Like all medicines, Bevatas 400 mg Injection may cause side effects, although not everyone experiences them. Side effects may vary in severity and usually depend on the patient’s condition and treatment duration.

Common Side Effects

Fatigue or weakness
Loss of appetite
Weight loss
Constipation or diarrhea
Nausea or vomiting
Fever
Dry skin or skin-related problems
Runny nose
Back pain
Numbness or tingling in hands and feet

Serious Side Effects

Seek immediate medical attention if any of the following occur:

High blood pressure
Severe headache or confusion
Vision changes
Severe allergic reactions
Delayed wound healing
Protein in urine
Severe infections
Blood clots in blood vessels or lungs
Gastrointestinal perforation
Increased risk of bleeding (including nosebleeds)
Heart-related problems or irregular heartbeat
Shortness of breath

Warning and Precaution

Bevatas 400 mg Injection may increase the risk of high blood pressure, bleeding, blood clots, and delayed wound healing
Avoid use at least 28 days before and after major surgery, as it may interfere with wound healing and increase bleeding risk
Use effective contraception during treatment and for at least 6 months after the last dose, as this medicine may cause harm to an unborn baby
Not recommended during pregnancy or breastfeeding
Use with caution in patients with:
- Heart disease or history of blood clots
- High blood pressure or diabetes
- Stomach or intestinal disorders (such as ulcers or colitis)
Monitor regularly for:
- Blood pressure changes
- Protein in urine
- Signs of infection or bleeding
Inform your doctor before treatment if you have dental problems or require surgery
Report immediately if you experience:
- Severe headache, confusion, or vision changes
- Chest pain or shortness of breath
- Severe abdominal pain
- Unusual bleeding or poor wound healing