Abirapro 250 mg Tablet

Brand Name: Abirapro

Molecule: Abiraterone Acetate

Strength: 250 mg

Quantity: 120 Tablets

Form: Tablet

Packaging Type: Bottle

Manufacturer/Marketed By: Glenmark

Country of Origin: India

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Description

Abirapro 250 mg is a prescription oral medication that contains Abiraterone Acetate, a potent androgen biosynthesis inhibitor used in the management of advanced prostate cancer, particularly metastatic prostate cancer, a stage where cancer has spread beyond the prostate gland to other parts of the body. This medication is commonly prescribed in combination with prednisone or prednisolone, a corticosteroid that helps manage potential side effects, such as mineralocorticoid excess (e.g., fluid retention, high blood pressure, or low potassium levels). Abirapro 250 mg targets the source of the problem by blocking an enzyme called CYP17A1, which is crucial for the production of androgens, including testosterone, a male hormone. Prostate cancer cells depend on testosterone to grow and multiply—even after the testicles stop producing it. Abirapro reduces testosterone production from all sources in the body, including the adrenal glands and the tumor itself, making it highly effective in castration-resistant prostate cancer (CRPC) and castration-sensitive prostate cancer (CSPC) when used appropriately. This targeted approach slows down or even stops the growth of cancer cells, and in many cases, contributes to longer survival and improved quality of life.

Benefits

Slows or Halts Tumor Growth: By blocking androgen production throughout the body, including in the adrenal glands and the tumor itself, Abirapro deprives prostate cancer cells of the hormones they need to grow.
Improves Survival Outcomes: Clinical trials show that abiraterone acetate significantly extends both progression-free survival (PFS) and overall survival (OS) in men with advanced prostate cancer.
Convenient Home-Based Therapy: When taken as an oral tablet, Abirapro enables patients to manage their treatment outside a hospital setting, promoting greater comfort and adherence.
Reduced Inflammation and Side Effects with Prednisone: Coadministration with corticosteroids helps manage inflammation, reduce fluid retention, and maintain electrolyte balance, which are key factors in managing hormone therapy side effects.

Indications and Usage

Abirapro 250 mg (Abiraterone Acetate) is approved for the treatment of prostate cancer in adult men under two main clinical conditions:

1. Metastatic Castration-Resistant Prostate Cancer (mCRPC):

This refers to prostate cancer that has spread to other parts of the body and continues to grow despite medical or surgical efforts to lower testosterone levels (castration). In this setting, Abirapro helps control tumor growth when traditional androgen deprivation therapy (ADT) is no longer effective.

2. Metastatic High-Risk Castration-Sensitive Prostate Cancer (mCSPC):

This is newly diagnosed, advanced prostate cancer that is still responsive to hormone therapy. Abirapro is used in combination with hormone suppression strategies (e.g., LHRH analogs) to delay disease progression and reduce complications.

Combination Therapy:

Abirapro is almost always prescribed alongside low-dose corticosteroids like prednisone or prednisolone to:

Reduce side effects related to hormone imbalance
Prevent adrenal insufficiency
Support overall treatment effectiveness.

It may also be used with LHRH analogs to maintain testosterone suppression as part of a comprehensive prostate cancer treatment plan.

How it Works

Abirapro 250 mg contains Abiraterone Acetate, a targeted cancer therapy classified as an androgen biosynthesis inhibitor. It works by blocking a key enzyme called CYP17A1 (17α-hydroxylase/C17,20-lyase)—an enzyme that plays a vital role in the production of androgens (male hormones), including testosterone.

Why Target Testosterone?

Prostate cancer cells are fueled by testosterone. Even after the testicles stop producing it (through hormone therapy or surgery), the body can still make small amounts of testosterone in:

Adrenal glands
Tumor tissues themselves

Abirapro interrupts this backup supply by stopping CYP17A1 from producing testosterone in all these sites. This reduces hormone levels to nearly undetectable levels, starving the cancer cells and slowing or stopping their growth.

What Makes It Effective?

It targets multiple hormone-producing sites (not just the testicles)
Works even when other treatments have failed to suppress hormone levels
Used alongside prednisone to balance out hormone levels and reduce side effects like fluid retention or high blood pressure

This mechanism makes Abirapro highly effective in managing both castration-resistant and castration-sensitive prostate cancer.

Dosage & Administration

Recommended Dosage

Take Abirapro 250 mg as 1000 mg once daily, which equals four 250 mg tablets.
Take it in combination with prednisone (5 mg twice daily), unless your doctor advises otherwise.

How to Take

Take Abirapro on an empty stomach—either 1 hour before or 2 hours after a meal.
Swallow the tablets whole with a full glass of water.
Do not crush, chew, or split the tablets.

Frequency

Take Abirapro once a day, ideally at the same time each day, to maintain consistent blood levels.

Missed Dose

If you miss a dose and less than 12 hours have passed, take it as soon as you remember.
If more than 12 hours have passed, skip the missed dose and resume your regular schedule.
Never take two doses at once to make up for a missed dose.

Overdose Warning

Contact your doctor or go to the emergency room immediately if you suspect an overdose.
Watch for signs like:

Unusual tiredness or weakness
Dizziness or low blood pressure
Yellowing of the skin or eyes (possible liver damage)

While taking Abirapro 250 mg, you may experience side effects. Some are mild and manageable, while others may require immediate medical attention. Always report any unusual or persistent symptoms to your healthcare provider.

Common Side Effects of Abirapro 250 mg

You may commonly experience:

Joint swelling or joint pain
Fatigue or general weakness
Increased blood pressure
Hot flashes or episodes of warmth
Fluid retention or swelling in the legs/feet
Low potassium levels, which may cause muscle weakness or cramps

Your doctor may order blood tests regularly to monitor these effects and adjust your treatment if needed.

Serious Side Effects of Abirapro 250 mg

Seek immediate medical help if you experience:

Liver problems: yellowing of the skin or eyes, dark urine, nausea, or abdominal pain
Adrenal gland issues: dizziness, vomiting, or unusual tiredness due to hormone imbalance
Heart rhythm problems: irregular heartbeat, chest pain, or fainting
Severe allergic reactions: rash, itching, swelling, severe dizziness, or trouble breathing

Always report any concerning side effects to your healthcare provider promptly. They may adjust your dose, recommend supportive treatment, or switch your medication if needed.

Warning and Precaution

Follow these safety guidelines carefully to reduce risks and ensure Abirapro 250 mg works effectively:

Pregnancy & Reproductive Warning

Do not use Abirapro if you are a woman—this medicine is strictly for male patients.
Abiraterone can harm an unborn baby if handled or taken by a pregnant woman.
Male patients with partners of childbearing potential must use effective contraception during treatment and for 3 weeks after the last dose.

Monitor Blood Pressure

Abirapro may raise blood pressure, especially when taken long-term.
Check your blood pressure regularly and report significant increases to your doctor.

Monitor Liver Function

Abiraterone can affect liver health.
Your doctor will schedule regular liver function tests (LFTs) to check for early signs of liver damage.
Report symptoms like yellowing of the skin/eyes, dark urine, or persistent nausea.

Take on an Empty Stomach

Always take Abirapro on an empty stomach—at least 1 hour before or 2 hours after eating.
Taking it with food may increase drug absorption, raising the risk of side effects.

Watch for Drug Interactions

Inform your doctor about all medications, supplements, and herbal products you are currently taking.
Certain drugs (e.g., antifungals, seizure medicines, blood thinners) can interfere with how Abirapro works or increase side effects.

Patient Guidance

Storage

Store Abirapro 250 mg at room temperature between 20°C to 25°C (68°F to 77°F).
Keep the tablets away from moisture, heat, and direct sunlight.
Do not store the medication in bathrooms or damp places.

Handling

Keep the tablets in their original packaging until you are ready to take them.
Do not use the medication if the tablets appear discolored, broken, or damaged.

Disposal

Do not flush Abirapro down the toilet or pour it into drains.
Safely dispose of unused or expired tablets through a local medicine take-back program, or ask your pharmacist for proper disposal methods.

Safety

Always store the medication out of reach of children and pets to prevent accidental ingestion.
Do not share this medication with anyone, even if they have similar symptoms, as it is prescribed based on individual medical conditions.

Clinical Trial & Approvals

Regulatory Approval

The U.S. Food and Drug Administration (FDA) first approved abiraterone acetate in 2011 for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in men who had previously received chemotherapy with docetaxel.
In 2012, the FDA expanded the approval to include men with metastatic castration-resistant prostate cancer (mCRPC) who had not received chemotherapy.
In 2018, the FDA approved abiraterone in combination with prednisone for the treatment of metastatic high-risk castration-sensitive prostate cancer (mCSPC).

These approvals have made abiraterone a cornerstone treatment for advanced prostate cancer.

Key Clinical Trials

COU-AA-301 Trial

Population: Men with mCRPC previously treated with chemotherapy.
Result: Abiraterone plus prednisone significantly improved overall survival (14.8 vs. 10.9 months compared to placebo).
Reference: de Bono JS et al., N Engl J Med 2011; 364:1995–2005

COU-AA-302 Trial

Population: Chemotherapy-naïve men with mCRPC.
Result: Abiraterone plus prednisone delayed disease progression and extended overall survival compared to placebo.
Reference: Ryan CJ et al., N Engl J Med 2013; 368:138 48

These pivotal trials demonstrated the effectiveness of abiraterone in slowing disease progression, improving survival, and delaying the need for chemotherapy, leading to its widespread use and global approval.

References

MedlinePlus – Abiraterone Oral
U.S. National Library of Medicine provides detailed consumer drug information. Click here
Mayo Clinic – Abiraterone (Oral Route)
Offers medically reviewed guidance on dosage, usage, and safety.Click here

WebMD – Abiraterone Overview
Includes patient-friendly drug information, side effects, and warnings about potential interactions. Click here

DrugBank – Abiraterone Acetate (DB05812)
Provides detailed pharmacological and molecular data on abiraterone. Click here

FAQ

What is the use of Abirapro 250 mg Tablet?+

Abirapro 250 mg is used to treat prostate cancer in men, particularly metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC). It works by reducing androgen production, which helps slow the growth of prostate cancer cells.

How does Abirapro 250 mg Tablet work in the body?+

Abirapro contains abiraterone acetate, which inhibits the CYP17 enzyme involved in the production of androgens. By blocking this enzyme, the medication lowers testosterone levels, thereby slowing or stopping the growth of prostate cancer cells.

How should I take Abirapro 250 mg Tablet?+

Take four 250 mg tablets (totaling 1000 mg) once daily on an empty stomach. Do not eat for at least two hours before taking the medication and for one hour after taking it. Swallow the tablets whole with water; do not crush or chew them. Always take Abirapro in combination with prednisone or prednisolone as prescribed by your doctor.

What is the price of Abirapro 250 mg Tablet?+

The Abiraterone 250 mg price in the Global (120 tablets) may vary. Tap the “Inquiry” button to check the latest price and availability!

Is Abiraterone the active ingredient in Abirapro 250 mg?+

Yes, Abirapro contains abiraterone acetate as its active ingredient. It is a generic version of the brand-name drug.

Is Abiraterone a chemotherapy drug?+

No, Abiraterone is not a chemotherapy drug. It is a type of hormone therapy that works by slowing down androgen production, which is essential for the growth of certain prostate cancers.

What is the target of Abiraterone?+

Abiraterone targets the CYP17 enzyme, which plays a crucial role in the production of androgens, or male hormones. By holding back this enzyme, abiraterone reduces androgen levels, slowing the progression of prostate cancer.

How long should abiraterone 250mg be taken?+

The duration of Abiraterone treatment varies depending on the individual’s response and tolerance. Patients typically continue the medication as long as it remains effective and side effects are manageable.

What happens when you stop taking Abiraterone 250 mg tablets?+

Stopping Abiraterone can lead to an increase in androgen levels, potentially causing the prostate cancer to progress. Always consult your doctor before discontinuing the medication.

What are the benefits of Abiraterone?+

Abiraterone has been shown to prolong survival, delay disease progression, and improve quality of life in men with advanced prostate cancer. It is particularly effective when combined with prednisone.

When is the best time to take abiraterone?+

Abiraterone should be taken once daily on an empty stomach, either one hour before or two hours after a meal, to ensure optimal absorption.

What are the brand names for abiraterone 250 mg?+

Brand names for abiraterone 250 mg include Zytiga. Generic versions are also available under various names.

Can Abirapro 250 mg Tablet cure prostate cancer?+

Abirapro does not cure prostate cancer but helps manage and control the disease, prolonging survival and improving quality of life.

Can I take Abirapro 250 mg Tablet with food?+

No, Abirapro should be taken on an empty stomach. Food can increase the absorption of abiraterone, resulting in higher blood levels and potentially increased side effects.

Can women take Abirapro 250 mg Tablet?+

Abirapro is not considered for use in women. Pregnant women should avoid handling the tablets due to potential risks to the fetus.

What should I do if I accidentally take too many Abirapro 250 mg Tablets?+

If you take more than the prescribed dose, contact your doctor immediately or seek emergency medical attention.

Can I take Abirapro 250 mg with other medications?+

Abirapro can interact with other medications. Inform your doctor about all the medicines you are taking to avoid potential interactions.

What are the risks and benefits of taking Abirapro 250 mg?+

Benefits include slowing the progression of cancer and improving survival rates. Risks may include side effects such as high blood pressure, liver issues, and electrolyte imbalances. Regular monitoring is essential.

Can I stop taking Abirapro 250 mg if I feel better?+

Do not stop taking Abirapro without consulting your doctor, even if you feel better, as the cancer may progress.

Who should not take Abirapro 250 mg?+

Abirapro is not recommended for women, especially those who are pregnant or breastfeeding, and individuals with severe liver impairment. Always consult your doctor before starting the medication.

What if I miss a dose of Abirapro 250 mg Tablet?+

If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one and continue with your regular schedule.

Can Abirapro 250 mg Tablet cure prostate cancer?+

No, Abirapro 250 mg does not cure prostate cancer. It is used to manage and control the disease, especially in advanced stages. The medicine helps slow down the growth and spread of cancer cells, reduces symptoms, and improves survival and quality of life in men with prostate cancer. However, it is not a permanent cure.

Can Abirapro 250mg Tablet worsen liver diseases?+

Yes, Abirapro can affect liver function and may worsen pre-existing liver problems. The medicine is processed in the liver, and in some cases, it can cause liver enzyme levels to rise or lead to liver damage. Regular liver function tests are recommended during treatment to monitor liver health. Patients with severe liver impairment should avoid using this medication unless advised otherwise by their doctor.

Why do I need to take prednisolone with Abirapro 250mg Tablet?+

Prednisolone is prescribed with Abirapro to help reduce specific side effects caused by abiraterone, such as high blood pressure, low potassium levels, and fluid retention. Abiraterone affects the adrenal glands, potentially leading to an increase in the production of other hormones. Prednisolone helps balance these hormones and makes the treatment safer and more effective.

Where to Buy Abiraterone Acetate 250 mg in the Global?+

You can buy Abirapro Abiraterone Acetate 250 mg from MedsMonks, which offers nationwide delivery.