Zydrox 500 mg Capsule

Description

Zydrox 500 mg Capsule is an oral chemotherapy medicine containing Hydroxyurea, used to treat certain cancers and blood disorders. Manufactured by Zuvius Lifesciences, Zydrox belongs to a class of drugs called antimetabolites, which work by slowing or stopping the growth of abnormal cells in the body. Zydrox 500 mg is commonly prescribed for leukemia, sickle cell disease, and other conditions involving abnormal blood cell production. It is available in capsule form for convenient daily use under medical supervision.

Benefits

• Helps slow or stop cancer cell growth
• Controls abnormal blood cell production
• Reduces painful crises in sickle cell disease
• Improves overall disease management
• Easy-to-use oral capsule formulation

Indications and Usage

Zydrox 500 mg Capsule is used in the treatment of:

• Chronic Myeloid Leukemia (CML)
• Head and Neck Cancer
• Solid Tumors
• Sickle Cell Disease
• Polycythemia Vera (off-label)
• Essential Thrombocythemia (off-label)

It may also be used along with radiation therapy in selected cancer cases.

How it Works

Zydrox contains Hydroxyurea, which:

• Blocks an enzyme called ribonucleotide reductase
• Prevents DNA synthesis in rapidly dividing cells
• Stops the multiplication of cancer cells

This helps control disease progression and abnormal blood cell production.

Dosage & Administration

Use only as prescribed by your doctor.

General dosage guidelines:

• Cancer (Solid Tumors / Head & Neck):
  • 20–30 mg/kg daily OR
  • 80 mg/kg every 3 days
• Chronic Myeloid Leukemia:
  • 20–30 mg/kg once daily
• Sickle Cell Disease:
  • Starting dose: 15 mg/kg/day
  • Gradual increase based on response
  • Maximum: 35 mg/kg/day

Take the capsule with water, with or without food, at the same time each day.

Side Effects

Like all chemotherapy medicines, Hydroxyurea may cause side effects.

Common side effects:

• Nausea and vomiting
• Loss of appetite
• Constipation or diarrhea
• Weakness and fatigue

Serious side effects:

• Bone marrow suppression
• Low white blood cells (infection risk)
• Low platelets (bleeding risk)
• Mouth ulcers
• Skin darkening or rash

Regular blood tests (CBC) are required during treatment.

Warning and Precaution

• Avoid during pregnancy (risk of birth defects)
• Use reliable contraception during treatment
• Not recommended during breastfeeding
• Regular monitoring required:
  • Blood counts
  • Liver function
  • Kidney function
• Increased risk of:
  • Infections
  • Secondary cancers (long-term use)

Patient Guidance

• Take exactly as prescribed
• Do not skip or double doses
• Stay hydrated
• Avoid exposure to infections
• Immediately report:
  • Fever
  • Bleeding
  • Severe fatigue

Regular follow-ups and blood tests are essential.

Clinical Trial & Approvals

Hydroxyurea, the active ingredient in Zydrox, is:

• Widely used in oncology and hematology
• Clinically proven to:
  • Reduce complications in sickle cell disease
  • Improve control in leukemia
• Included in international treatment guidelines