Bavencio 200 mg Injection

Brand Name: Bavencio

Molecule: Avelumab

Strength: 200 mg

Quantity: 1 Vial

Form: Injection

Packaging Type: Vial

Manufacturer/Marketed By: Merck

Country of Origin: India

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Overview

- Introduction
- Benefits
- Indications and Usage
- How it Works
- Dosage & Administration
- Side Effects
- Warning and Precaution

Description

Bavencio 200 mg Injection contains Avelumab, an immunotherapy medicine used in the treatment of certain advanced cancers. It is a monoclonal antibody that enhances the body's immune response to identify and attack cancer cells. Bavencio is administered intravenously under the supervision of an oncologist in a medical facility.

Benefits

Enhances the immune system’s ability to target cancer cells
Improves treatment outcomes in patients with advanced cancers
Provides a survival benefit in metastatic disease
Safe for long-term maintenance therapy in responsive patients
Effective when used alone or in combination with targeted therapy (e.g., axitinib)

Indications and Usage

Bavencio 200 mg Injection is prescribed for:

Metastatic Merkel Cell Carcinoma (MCC)
Locally advanced or metastatic Urothelial Carcinoma (UC) after disease progression
Advanced Renal Cell Carcinoma (RCC) in combination with axitinib
Certain other cancers as recommended by an oncologist

Usage must be guided and monitored by a cancer specialist.

How it Works

Avelumab is a PD-L1 inhibitor (Programmed Death-Ligand 1 inhibitor).

Cancer cells express PD-L1 to evade immune detection.
Bavencio blocks this PD-L1 signal, enabling T-cells (immune cells) to recognize and destroy cancer cells.
This restores and strengthens the immune system’s natural anti-tumor activity.

Dosage & Administration

Administered as an intravenous infusion
Standard dose: 800 mg every 2 weeks (depending on regimen)
Each infusion is given over approximately 60 minutes
Premedication may be given to reduce infusion-related reactions
Treatment continues until disease progression or unacceptable toxicity

Important: Bavencio should only be administered in a hospital or oncology center by trained healthcare professionals.

Side Effects

Common side effects:

Fatigue
Nausea
Diarrhea
Rash or itching
Muscle or joint pain
Fever or chills

Serious side effects (seek immediate medical attention):

Immune-related reactions:
- Pneumonitis (lung inflammation)
- Hepatitis (liver inflammation)
- Nephritis (kidney inflammation)
- Colitis (severe diarrhea)
- Endocrine disorders (thyroid/adrenal dysfunction)
Severe infusion reactions
Severe allergic responses

Warning and Precaution

Not recommended during pregnancy or breastfeeding
Monitor for immune-related side effects (lungs, liver, kidneys, colon, hormones)
Regular blood tests required during treatment
Inform doctor if you have autoimmune diseases
Use cautiously in patients with organ transplants
Report any of the following immediately:
- Persistent cough, chest pain, or difficulty breathing
- Severe abdominal pain or diarrhea
- Yellowing of eyes/skin
- Unusual fatigue or dizziness
- Severe rash or swelling
Avoid live vaccines during treatment