Written by:
Dr. Sophie Reynolds

Dr. Sophie Reynolds is a board-certified medical doctor specializing in internal medicine. With over a decade of experience in patient care and medical writing

Alimta 500 mg Injection

Brand Name:   Alimta
Molecule:   Pemetrexed
Strength:   500 mg
Quantity:   1 Vial
Form:   Injection
Packaging Type:   Vial
Manufacturer/Marketed By:   Eli Lilly And Company
Country of Origin:   India
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Description

Alimta 500mg Injection contains Pemetrexed, a chemotherapy medicine used to treat non-small cell lung cancer and malignant pleural mesothelioma. It slows cancer cell growth and is administered under oncologist supervision.

Benefits

  • Helps slow cancer growth and spread

  • Improves treatment outcomes in eligible lung cancer patients

  • Effective when combined with platinum-based chemotherapy

  • Well-established standard of care in NSCLC and mesothelioma

Indications and Usage

Alimta 500mg Injection is indicated for:

  • Non-squamous Non-Small Cell Lung Cancer (NSCLC)

  • Malignant Pleural Mesothelioma

  • May be used alone or in combination with other chemotherapy medicines (e.g., cisplatin)

Therapy must be initiated and supervised by an oncologist.

How it Works

Pemetrexed inhibits multiple folate-dependent enzymes required for DNA and RNA synthesis. By blocking these pathways, it prevents cancer cells from dividing and growing, leading to tumor control.

Dosage & Administration

  • Dose determined based on body surface area (BSA) and clinical condition

  • Given as an intravenous infusion every 3 weeks

  • Folic acid, vitamin B12, and corticosteroids are typically prescribed before treatment

  • Do not self-administer—must be given in a medical facility

  • Requires regular blood tests and kidney function monitoring

Side Effects

Common side effects:

  • Fatigue or weakness

  • Nausea, vomiting, or loss of appetite

  • Mouth sores

  • Rash or itching

  • Low blood cell counts (anemia, neutropenia)

Serious side effects (seek urgent care):

  • Severe infection or fever

  • Kidney problems

  • Breathing difficulty

  • Severe allergic reaction

  • Unusual bleeding or bruising

Warning and Precaution

  • Not recommended during pregnancy or breastfeeding

  • Avoid use in severe kidney impairment unless advised

  • Monitor blood counts, liver and kidney function regularly

  • Inform doctor about ongoing medicines, especially NSAIDs

  • Increased risk of infection — report fever immediately

  • Maintain adequate hydration unless restricted

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