Written by:
Dr. Sophie Reynolds
Dr. Sophie Reynolds is a board-certified medical doctor specializing in internal medicine. With over a decade of experience in patient care and medical writing
Alimta 500 mg Injection
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Description
Alimta 500mg Injection contains Pemetrexed, a chemotherapy medicine used to treat non-small cell lung cancer and malignant pleural mesothelioma. It slows cancer cell growth and is administered under oncologist supervision.
Benefits
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Helps slow cancer growth and spread
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Improves treatment outcomes in eligible lung cancer patients
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Effective when combined with platinum-based chemotherapy
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Well-established standard of care in NSCLC and mesothelioma
Indications and Usage
Alimta 500mg Injection is indicated for:
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Non-squamous Non-Small Cell Lung Cancer (NSCLC)
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Malignant Pleural Mesothelioma
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May be used alone or in combination with other chemotherapy medicines (e.g., cisplatin)
Therapy must be initiated and supervised by an oncologist.
How it Works
Pemetrexed inhibits multiple folate-dependent enzymes required for DNA and RNA synthesis. By blocking these pathways, it prevents cancer cells from dividing and growing, leading to tumor control.
Dosage & Administration
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Dose determined based on body surface area (BSA) and clinical condition
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Given as an intravenous infusion every 3 weeks
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Folic acid, vitamin B12, and corticosteroids are typically prescribed before treatment
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Do not self-administer—must be given in a medical facility
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Requires regular blood tests and kidney function monitoring
Side Effects
Common side effects:
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Fatigue or weakness
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Nausea, vomiting, or loss of appetite
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Mouth sores
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Rash or itching
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Low blood cell counts (anemia, neutropenia)
Serious side effects (seek urgent care):
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Severe infection or fever
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Kidney problems
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Breathing difficulty
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Severe allergic reaction
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Unusual bleeding or bruising
Warning and Precaution
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Not recommended during pregnancy or breastfeeding
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Avoid use in severe kidney impairment unless advised
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Monitor blood counts, liver and kidney function regularly
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Inform doctor about ongoing medicines, especially NSAIDs
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Increased risk of infection — report fever immediately
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Maintain adequate hydration unless restricted
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