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Combinib 250 mg Tablet

Brand Name: Combinib

Molecule: Lapatinib

Strength: 250 mg

Quantity: 30 Tablets

Form: Tablet

Packaging Type: Bottle

Manufacturer/Marketed By: Cipla

Country of Origin: India

Description

Combinib 250 mg Tablet contains Lapatinib, a targeted anticancer agent used in the treatment of HER2-positive breast cancer. It is a tyrosine kinase inhibitor (TKI) that blocks specific proteins responsible for cancer cell growth and spread. Combinib is typically used in combination with other anticancer drugs in patients who have advanced or metastatic breast cancer.

Benefits

Specifically targets HER2-positive cancer cells
Delays progression of metastatic breast cancer
Oral administration allows at-home treatment
Often used when resistance to trastuzumab or chemotherapy occurs
Can be combined with hormone therapy or chemotherapy

Indications and Usage

Combinib (Lapatinib) is indicated for the treatment of:

Advanced or metastatic HER2-positive breast cancer
- In combination with capecitabine in patients previously treated with anthracyclines, taxanes, and trastuzumab
- In combination with letrozole for postmenopausal women with hormone receptor–positive, HER2-positive metastatic breast cancer

It must be prescribed and monitored by a qualified oncologist.

How it Works

Lapatinib blocks the HER2/neu and EGFR (ErbB1) tyrosine kinases — proteins that promote growth and survival of cancer cells. By inhibiting these signaling pathways, Combinib slows or stops tumor cell growth, especially in HER2-positive breast cancer.

Dosage & Administration

Dosage is determined by your oncologist based on your condition and combination therapy
Typically taken once daily on an empty stomach (1 hour before or 1 hour after meals)
Must be swallowed whole with water — do not crush or chew
Do not skip or stop treatment unless advised by your doctor
Regular monitoring of liver function and cardiac status may be required

Side Effects

Common side effects:

Diarrhea
Nausea or vomiting
Rash or skin irritation
Loss of appetite
Fatigue
Mouth sores

Serious side effects (seek medical attention):

Liver enzyme elevation or liver toxicity
Dehydration due to severe diarrhea
Heart rhythm changes (rare)
Interstitial lung disease (rare)

Warning and Precaution

Not recommended in pregnancy or breastfeeding
May cause liver damage — monitor liver enzymes
Use with caution in patients with heart disease or lung problems
May cause severe diarrhea — hydration and antidiarrheal medications may be needed
Inform your doctor about all medications and supplements
Avoid grapefruit juice as it may affect drug levels